Samuels is the daughter of Kathy, a producer for unscripted series, and Scott, a U.S. marshal. She has three brothers, Cody, Harrison, and Jack, and one sister, Heather.
She studied Marketing and Intellectual Property at Stanford University. Taking off a quarter to film Scream Queens, she returned to school in January 2016 and graduated in June 2016. She was a member of the Kappa Alpha Theta sorority.
- Skyler's nickname is Skye.
- She has three brothers and one sister.
- Her star sign is Aries.
- She was born 1994 and is the same age as her character Chloe King.