Coppola started her TV career as a hostess on the MTV game show Remote Control. In 1991, she was hired to play vixen Lorna Devon on the soap opera Another World; she played the role until 1994. Her better-known TV jobs include a recurring role on Trinity (1998–1999), a starring role on the American remake of the British comedy Cold Feet(1999), and top billing on the TNT drama Bull (2000). She appeared briefly as Lt. Stadi in the pilot episode of Star Trek: Voyager, played a murderer on CSI: Crime Scene Investigation and a widow who marries her late husband's killer on Law & Order: Criminal Intent, and appeared several times as a military lawyer on JAG and NCIS (she also appeared in an episode of NCIS: Los Angeles, but as a different character). Coppola also took on the unusual role of a female serial killer agreeing to help catch her copycat in the 2005 episode of Crossing Jordan titled "Road Kill". She had a recurring role on NBC's American Dreams playing the role of Nancy. She appeared in Two and a Half Men as Dr. Michelle Talmadge, in episode Woo-Hoo, a Hernia-Exam! (2005).
Coppola also had a role as a Muslim intelligence analyst working for the Los Angeles branch of the Counter Terroris Unit (CTU), in a single episode of 24, named Azara (1–2 am during Day 4). All four of her scenes were cut from the broadcast episode, but are restored as extras on the Day 4 DVD. In them, she discovers a lead in the investigation which is originally dismissed by fellow analyst Edgar Stiles, who suspects her because of her religion. Edgar later apologizes to her when her lead turns out to be important.
Starting in the fall of 2006, she appeared in the recurring role of IRS Agent Mimi Clark in the post-apocalyptic drama Jericho. She became a series regular in February 2007. She was an FBI agent in National Treasure: Book of Secrets, also directed by Jericho executive producer Jon Turteltaub.
Born in Huntington, New York, Coppola earned a bachelor's degree from New York University in 1990. Although not related to film director Francis Ford Coppola, she is the sister and cousin of film producers Matthew Coppola and Denise Di Novi, respectively.
Coppola guest-starred on the season 2 episode "Little Angels" of CBS' NCIS: Los Angeles, playing FBI agent Amy Rand, an expert on kidnapping cases.